Impact of uric acid changing degrees on kidney function in middle-aged and elderly women——A follow-up cohort study

Objective To determine the impact of uric acid changes on kidney function in middle-aged and elderly women with normal renal function. Methods Serum uric acid and estimated glomerular filtration rate(eGFR) were studied by prospective cohort analysis in 1152 middle-aged and elderly Dalian women with serum uric acid 45 years old. Results The analysis of variance (ANOVA) of clinical indices between baseline and follow-up data showed that an eGFR was decreased after three years in both middle-aged and elderly women even with normal serum uric acid. Compared with those in the lowest guartile subgroup, a significant drop of eGFR to less than 90 ml·min-1·(1.73 m2)-1 was seen in those with the highest guartile of baseline serum uric acid group (OR=1.707, 95%CI 1.192-2.443, P=0.003). Furthermore, there were positive correlations between changes in the levels of serum uric acid and eGFR, and linear regression analysis showed that, as the change level of serum uric acid increased, the change level of eGFR declined(β=1.562, 95%CI 1.050-2.075, P<0.01], and the changing degree of uric acid increase is independent risk factors refor eGFR reductions. Conclusion Reduction in eGFR level is inversely related to serum uric acid in perimenopausal and postmenopausal women. However, our study showed that, women with serum uric acid level ranging from normal, slight increase, and relatively high levels, the increasing degrees of uric acid are independent risk factors responsible for the changing degree of eGFR reduction. (Chin J Endocrinol Metab, 2017, 33: 392-397) Key words: Middle-aged and elderly; Uric acid; Estimated glomerular filtration rate