PHARMACOLOGY AND METABOLISM OF COMPOUND A

Abstract : Studies were carried out to determine the pharmacological activity and the metabolic fate of Compound A, (ClF5). The project was planned to determine pharmacological effects by evaluation of behavioral, physical, and biochemical changes induced by administration of the material. Preliminary studies were carried out to establish maximum tolerated doses. For this purpose it was elected to follow alterations in hepatic, renal, and metabolic function at those tolerated levels. The procedures employed included tests of dye excretion, blood coagulation, enzyme levels (serum and tissue transaminases as indices of cellular metabolism), blood chemical levels (urea nitrogen, glucose), and nitrogen balance studies to permit evaluation of the general physiological status of the test animals as affected by the exposure.