Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction

Aims/hypothesis Prostaglandin E2 (PGE2) is a well-recognised inhibitor of glucose-stimulated insulin secretion (GSIS). The aim of this study was to investigate the signalling pathway of PGE2 in beta cell function regulation in HIT-T15 cells and isolated rat islets.