The Promises of the Novel Connection Between HEXIM and Hedgehog Signalling

Despite the profusion of molecular data describing the biochemical interactions between HEXIM and its partners, very little is known about its physiological function. In recent works, we provided in vivo data showing that HEXIM is a key controller of Hedgehog signalling during wing morphogenesis. In this commentary, we discuss the known biological processes controlled by HEXIM in the light of our new results.