The Role of Oncogene c-met in Tumor Proliferation and Angiogenesis in Breast Cancer

Objective:To find the role of prooncogene c-met in tumor proliferation and angiogenesis in breast cancer so as to provide the theory of the possibility of a new prognosis prediction for breast carcinoma.Methods:By using immunohistochemical method and MVO(microvessel density),c-met protein expression and microvessel density were measured in 75 cases of breast carcinoma and 20 cases of breast fibroadenoma.Results:The expression of c-met in breast carcinoma tissues were significantly correlated with histologic grade,lymph node metastasis and tumor stage(P0.05),but it was insignificantly correlated with ages,lesion position,menopausal status,ER and PR,tumor size(P0.05).Positive rate of c-met expression was significantly correlated with microvessel count(P0.01).Conclusion:Prooncogene c-met was closely related with tumor proliferation and tumor angiogenesis.It could be one of valuable prognosis indicators in breast cancer.