Synthesis of serine in the liver of vertebrates
1966
Abstract 1. 1. The radioactivity of uniformly labeled C 14 -glucose is incorporated into phosphoserin and serine by liver extracts of rat, guinea pig, chicken, pigeon and turtle and into serine by liver extracts of frog, tench and eel. 2. 2. The technique of isotope competition shows that serine sythesis occurs through the phosphorylated pathway as well as through the non-phosphorylated one in rat, guinea pig and chicken, whereas in pigeon liver only the first one is operative. 3. 3. 3-Phosphoglycerate dehydrogenase and phosphohydroxypyruvate-glutamate transaminase are present in the liver of all the animals which we have studied, in contrast to phosphoserine phosphatase, which is absent in some of them (frog, tench and eel). 4. 4. Hydroxypyruvate-alanine transaminase is active in the liver of rat, guinea pig, chicken, frog, tench and eel, but not in pigeon and turtle liver. 5. 5. Serine-hydroxymethyltransferase is active in all the vertebrates which we have studied.
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