Studies on lung targeting gelatin microspheres of mitoxantrone
1995
Lung targeting
gelatin microspheres of mitoxantrone(DHA)were prepared by atwo-step
methed. The diameter of 87. 36%of the DHAQ gelatin microspheres
(DHAQ-GMS)was inthe range of 5.1 to 25.0 μm. Release of the drug
from the DHAQ-GMS in vitro became much slowerand its t1/2 was 4
times longer than that of pure DHAQ.The characteristic peak of heat
absorption onthe differential thermal analysis curve was at 133℃ and
almost no change was observed after theDHAQ-GMS were stored for 3
months at 37℃ (relative humidity 75%). The distribution test in
vivoin mice indicated that the lung targeting effect of the DHAQ-GMS
was obvious and that the targetingefficiency of the lung compared to
other organs and blood increased 3 to 35 times, Kinetic behavior
ofthe drug in mouse lung could be described by one open compartment
model, and the average residual time increased by 10h.
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