High Molecular Weight Phospholipase A2: Its Occurrence and Quantification in Human Colon Cancer and Normal Mucosa

Human colon tumors usually produced more prostaglandins compared with associated normal mucosa (Bennett et al. 1987) but the reason is not well understood. Lipid peroxidation, phospholipase A2 activity and myeloperoxidase activity were increased in colorectal cancers compared with macroscopically normal tissues (Otamiri et al. 1989). Varying amounts of total arachidonic acid in the phospholipids of colorectal tumors compared to normal associated mucosa have been reported (Yazici et al. 1991; Neoptolemos et al. 1991).