Effect of Renal Denervation and a-Adrenergic Blockade on Sodium Excretion in Dogs with Chronic Ligation of the Common Bile Duct

SummaryChronic ligation of the common bile duct (CBDL) is dogs causes sodium retention and a blunted natriuretic response to extracellular volume expansion (ECVE). Since increased sympatho-adrenal activity plays an important role in other sodium retaining states, the present study was undertaken to evaluate the role of renal denervation and a-adrenergic blockade on the renal handling of sodium in dogs with CBDL. Both renal denervation and the infusion of dibenzyline into the renal artery produced a slight but significant increment in urinary sodium excretion, but these changes were not different from those observed after renal denervation in normal animals. Also, these procedures did not improve the response to saline infusion in dogs with CBDL. These data indicate that the sympatho-adrenal activity does not play an important role in the salt retaining state that follows chronic ligation of the common bile duct.Anne Harrington and Miriam Bick provided technical help and Mrs. Catherine Hoyt provided secret...