manidipine therapeutic combinations and simvastatin.

ethyl methyl ester (a) 2- [4- (diphenylmethyl) -1-piperazinyl] acid (±) -1,4-dihydro-2,6-dimethyl-4-: appropriate for oral administration comprising pharmaceutical composition (3-nitrophenyl) -3,5piridinadicarboxilico (manidipine) or a physiologically acceptable salt thereof; (B) Simvastatin or a physiologically acceptable salt thereof; and (c) a pharmaceutically acceptable carrier or diluent; wherein manidipine and simvastatin are present in a fixed amount and quantitative ratio as fixed combination.