Salinazinones A and B: Pyrrolidinyl-Oxazinones from Solar Saltern-Derived Streptomyces sp. KMF-004.

Min Cheol Kim,Jung Hwan Lee,Bora Shin,Lalita Subedi,Jin Wook Cha,Jin-Soo Park,Dong-Chan Oh,Sun-Yeou Kim,Hak Cheol Kwon

Salinazinones A and B: Pyrrolidinyl-Oxazinones from Solar Saltern-Derived Streptomyces sp. KMF-004.

2016

Min Cheol Kim
Jung Hwan Lee
Bora Shin
Lalita Subedi
Jin Wook Cha
Jin-Soo Park
Dong-Chan Oh
Sun-Yeou Kim
Hak Cheol Kwon

Compounds (I) and (II) are evaluated for their inhibition activity towards LPS-induced NO-production by BV-2 microglia cells, with (I) inhibiting NO production without cellular toxicity and (II) being inactive.

Keywords:

Stereochemistry
Streptomyces
Microglia
Toxicity
Organic chemistry
Chemistry
no production

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