Chemotherapy of Tuberculosis III. In Vitro and in Vivo Activities of Various Compounds

Conclusions1. The synthetic medium described by Dubos and Davis provides an efficient method of studying antimyeobacterial agents. 2. Of 19 compounds tested in vitro, 4 showed sufficient activity to warrant further investigation. 3. 2-butoxy-5-amino-pyridine sodium formaldehyde bisulfite is ineffective in the treatment of experimental tuberculosis in mice and guinea pigs.