Genuine cutaneous amyloidosis. Natural course

: A case of primary localized cutaneous amyloidosis followed up during 35 years is reported. The initial lesions and the pruritus disappeared after years of evolution and new lesions appeared in other areas. These findings confirm previous observations of the author who reported on 24 patients with primary localized cutaneous amyloidosis followed up for 20 to 30 years. In seven of them amyloid was demonstrated in areas where clinical lesions had disappeared. In most patients either the clinical lesions the pruritus, or both had disappeared and in many patients other clinical lesions had appeared in other locations.