Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid

Abstract The preparation of the monounsaturated fatty acid, trans -vaccenic acid 4 (TVA), using both Wittig and one-pot Julia-Kocienski olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis -9- trans -11-conjugated linoleic acid 2 from trans -2-nonenal and (8-carboxyoctyl)triphenylphosphonium bromide 12 .