Research progress of amyloidosis nephropathy

The amyloidosis encompasses a group of diseases caused by the pathogenic misfolding of specific proteins that differ substantially with respect to organ involvement, management, and prognosis.Immunoglobulin light-chain associated (AL) and secondary (AA) amyloidoses are by far the most prevalent subtypes with renal involvement.Renal presentation mainly reflects glomerular deposits with proteinuria, often overt nephrotic syndrome, and varying renal insufficiency.However, where tubulointerstitial involvement predominates, particularly in some types of hereditary apolipoprotein A-1 amyloidosis, a gradual decline in renal excretory function, is obsewed without significant proteinuria.The use of mass spectrometry-based proteomics can the clearly idenfify precursor proteins and then typing.It's important to summarize the, histopathological characteristics of nephropathy amyloidosis, the clinical manifestations, and treatment methods. Key words: Amyloidosis; Amyloidosis nephropathy; Typing; Treatment