Precise installation of diazo-tagged side-chains on proteins to enable in vitro and in-cell site-specific labelling.

Barbara Bernardim,Lavinia Dunsmore,He Li,Brad Hocking,Reyes Nuñez-Franco,Claudio D. Navo,Gonzalo Jiménez-Osés,Antonio C. B. Burtoloso,Gonçalo J. L. Bernardes

Precise installation of diazo-tagged side-chains on proteins to enable in vitro and in-cell site-specific labelling.

2020

Barbara Bernardim
Lavinia Dunsmore
He Li
Brad Hocking
Reyes Nuñez-Franco
Claudio D. Navo
Gonzalo Jiménez-Osés
Antonio C. B. Burtoloso
Gonçalo J. L. Bernardes

The chemistry of diazo compounds has generated a huge breadth of applications in the field of organic synthesis. Their versatility combined with their tunable reactivity, stability, and chemoselect...

Keywords:

Biochemistry
Side chain
In vitro
Combinatorial chemistry
Diazo
Organic synthesis
specific labelling
Chemistry

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