Activity of angiotensin-converting enzyme inhibitors in venoms of central Asian snakes

The inhibition of angiotensin-converting enzyme (ACE, K.F.3.4.15.1) by low-molecular-weight fractions of venoms from central Asian snakes was studied using N-(3-[2-furyl]acryloyl)-Phe-Gly-Gly (FAPGG) as substrate. Their activity is substantial in peptide fractions of poisons from snakes of the Viperidae and Crotalidae families and completely absent in cobra poison (Elapidae).