Effect of dexmedetomidine on haemodynamic parameters in patients undergoing laparoscopic surgeries

Background: Pnuemoperitoneum created during laparoscopic surgeries cause adverse haemodynamic changes. Many drugs are used to blunt these effects. Dexmeditomidine is a highly selective alpha2 agonist, causes sympatholysis, analgesia and also has cardiovascular stabilizing property. Hence the present study is an attempt to study the effects of dexmeditomidine in attenuating these adverse haemodynamic effects. Methodology: A total of 60 patients were divided into two groups. Group D patients recieved dexmeditomidine at a rate of 0.2µg/kg/hour or 0.04ml/kg/hr and Group S patients recieved 0.9% Normal Saline at the same rate. Infusion was started 5 mins before induction. Heart rate, blood pressure, mean arterial pressure were monitored.Result: In group D haemodynamic stress response was significantly attenuated when compared to group S. Results were statistically significant.Conclusion: Dexmedetomidine, a highly selective alpha-2 agonist, when infused at a low dose of 0.2µg/kg/hour has stable hemodynamics during laparoscopic surgery.