New Initiatives in Combination Antiretroviral Chemotherapy

Although monotherapy with available antiretroviral agents has proved useful in terms of delaying disease progression and improving the survival of persons with AIDS, the utility of these compounds as single agents is limited by several factors, including incomplete suppression of viral replication, the emergence of resistant virus, and a gradual increase in viral burden over time.1,2 As the benefit of antiretroviral monotherapy wanes, immune function decreases, leading to disease progression and ultimately death.