Calcium Release and Influx in Yeast: TRPC and VGCC Rule Another Kingdom

Calcium is one of the most ubiquitous second messengers, in addition to being a fundamentally important cofactor for many proteins9 functions. Thus, cells from fungi to plants to animals have evolved mechanisms for carefully controlling calcium concentrations in their organelles and cytosol. This perspective discusses the similarities and differences between yeast and animals in cation channels of two families: the transient receptor potential channels (TRPCs) and voltage-gated calcium channels (VGCCs). One of the key differences highlighted is in the channels implicated in the response of yeast and animal cells to depletion of calcium from intracellular stores, and the differences in localization of these channels between yeast and animal cells. Understanding the logic of fungal Ca 2+ channels, therefore, may provide new insights into the organization and regulation of cellular calcium signaling networks in animals.