An Explore of MMP-2, MMP-9, VEGF and Survivin in the Diagnosis and Significiace of Malignant Ascites

Objective To explore the diagnostic value of MMP-2,MMP-9,VEGF and Survivin in malignant ascites and determine their significance in malignant ascites formation.Methods To detect MMP-2,MMP-9,VEGF and Survivin levels in various kinds of ascites and fluids of abdominal cavity by enzyme-linked immunosorbent assay(ELISA).Results MMP-2,MMP-9,VEGF and Survivin levels in malignant ascites were significantly higher than those of cirrhosis,tuberculous(P0.05).However,there were no significant difference of MMP-2,MMP-9,VEGF and Survivin levels among the latter 2 groups(P0.05).Conclusion The detection of MMP-2,MMP-9,VEGF and Survivin levels is useful in differential diagnosis of benign and malignant ascites.They may play an important role in malignant ascitesformation.