4-Acylhydrazone-5-Pyrazolones and Their Zinc(II) Metal Complexes: Synthesis, Characterization, Crystal Feature and Antimalarial Activity

Two novel 4-acylhydrazone-5-pyrazolones (L1=(Z)-N'-((4-chlorophenyl)(3-methyl-5-oxo-1-(p-tolyl)-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide and L2 = (Z)-N'-((4-chloro phenyl )(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide) were synthesized from 4-acyl-5-pyrazolone and benzoyl hydrazide and assessed for in silico and in vitro antimalarial activity. Synthesized one binary Zinc(II) complex 1 [Zn(L1)2]from L1. Two mixed ligands complexes 2 [Zn(L2)(bpy)(OAc)]EtOH and 3 [Zn(L2)(phen)(H2O)] were synthesized from L2 with 2,2’-bipyridine and 1, 10-phenanthroline, respectively. Ligands and complexes were characterized by 1H NMR, FT-IR, UV-Vis, Single crystal X-ray diffraction and conductance measurement. All compounds displayed decent outcomes in invitro antimalarial activity.