Desprendimiento experimental bioquímico reversible de la retina sin retinotomías para traslocación macular

SUMMARY Purpose. Creation of retinal detachment is an essential component of macular translocation. The purpose of the study is to avoid mechanical methods that damage the integrity of the retina and promote the appearance of PVR. Methods. Hialuronidase (0.30 ml) and ACS-300 (0.50 ml) at different concentrations were injected into de vitreous cavity of 10 pigmented rabbits with a two week separation between each other. All rabbits were observed at 24, 36 and 72 h and also 1, 2, 3 and 4 weeks by ophtalmoscopy. ERG was performed before, during and after to evaluate de safety of ACS-300. Three eyes were enucleated and examined by electronic microscopy. Results. In 87.5% of the eyes, partial or total retina detachment was observed in an average of time of 48 h, and in 100% of the eyes the retina reattached spontaneously in an average of time of 2-3 weeks. No adverse effects were detectable by ERG or electronic microscopy. Conclusions. Intravitreal injection of hialuronidase and ACS-300 is a safe non-mechanical method for creating retinal detachment in rabbits and that may be effective for macular translocation.