2-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenol leukotriene B4 receptor antagonists

Abstract A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenols were prepared and shown to be potent leukotriene B 4 (LTB 4 ) receptor antagonists. They bound to the human neutrophil and guinea pig lung LTB 4 receptors with high affinity. Each compound was also shown to be effective at antagonizing the effects of LTB 4 -induced integrin up-regulation on human neutrophils and on LTB 4 -mediated contraction of guinea pig lung parenchyma.