EFFICACY OF SINGLE DOSE OF VAGINAL MISOPROSTOL 800 µg IN FIRST TRIMESTER ABORTION.

OBJECTIVES : To know the efficacy and outcome of single dose of vaginal Misoprostol 800Ug in first trimester abortion. MATERIAL AND METHODS : This study was conducted over a period of 3 yrs at Adichunchanagiri institute of medical sciences. A total of 200 pregnant women upto 12 wks of gestation wanting termination of pregnancy was recruited in this study. The efficacy, outcome, and induction abortion interval was studied in these cases. RESULTS: In our case study 76% of the patients had complete abortion with single dose of 800ug Misoprostol and 4 % underwent check curettage due to profuse bleeding and retained products in uterus on USG. 20% of the cases needed second dose of 200ug of Misoprostol. The mean induction to abortion interval was 11.38hrs. 96% of the patients had complete abortion with medical method and only 4% underwent surgical curettage due to profuse bleeding after the single dose. The mean haemoglobin prior to induction was 9.76gm% and post expulsion was 9.59gm % respectively. No statistical difference was noted .The incidence of side effects like nausea, vomiting and diarrhoea was minimal and transitory. No major complications noted. CONCLUSION: Vaginal PGE 1 analogue is very safe and effective method of termination of first trimester pregnancy. Single high dose of vaginal Misoprostol 800ug is found to be cost -effective with minimal side effects, shorter Induction Abortion interval and a day care procedure with good success rate and can be adopted at community and primary health care units to reduce the maternal morbidity and mortality in developing countries like India due to unwanted pregnancies and unsafe abortions INTRODUCTION: The incidence of illegal abortion is twice as high as that of legal MTP'S.Many incidences have not been reported. Unwanted pregnancies due to failure to obtain appropriate contraceptive services and also unwillingness of the women result in both legal and illegal abortions. The complications of unsafe abortions can vary from chronic infection and infertility to septic shock syndrome ,multiorgan failure and death. Medical abortion is a safe,effective means of terminating pregnancy provided the