The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Annalisa Natalicchio,Federica Tortosa,Rossella Labarbuta,Giuseppina Biondi,Nicola Marrano,Emanuele Carchia,Anna Leonardini,Angelo Cignarelli,Marco Bugliani,Piero Marchetti,Gian Paolo Fadini,Marco Giorgio,Angelo Avogaro,Sebastio Perrini,Luigi Laviola,Francesco Giorgino

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

2015

Annalisa Natalicchio
Federica Tortosa
Rossella Labarbuta
Giuseppina Biondi
Nicola Marrano
Emanuele Carchia
Anna Leonardini
Angelo Cignarelli
Marco Bugliani
Piero Marchetti
Gian Paolo Fadini
Marco Giorgio
Angelo Avogaro
Sebastio Perrini
Luigi Laviola
Francesco Giorgino

Aims/hypothesis The role of the redox adaptor protein p66Shc as a potential mediator of saturated fatty acid (FA)-induced beta cell death was investigated.

Keywords:

Lipotoxicity
Signal transducing adaptor protein
Shc Signaling Adaptor Proteins
Phosphorylation
Beta cell
Internal medicine
Endocrinology
Signal transduction
Apoptosis
Biology
Biochemistry
Fatty acid
saturated fatty acid

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