Expression of Mig-7 and vasculogenic mimicry in glioma and their clinical significance

Objective: To investigate the expression of migration-inducing protein 7 (Mig-7) and vasculogenic mimicry (VM) in glioma and their clinical significance.Methods: The expressions of Mig-7 in glioma tissues and normal control tissues (traumatic brain tissues) were detected by immunohistochemistry and Western blotting, respectively. The VM in glioma tissues was determined by CD34 and periodic acid-Schiff (PAS) staining method. The associations of the expression of Mig-7 and VM with the clinicalpathological characteristics of patients with glioma were analyzed. The relationship between the expression of Mig-7 and the survival of patients with glioma was also analyzed.Results: The positive expression rates of Mig-7 in glioma tissues and the normal brain tissues were 56.7% (34/60) and 0% (0/10), respectively. The expression level of Mig-7 in grades Ⅰ and Ⅱ glioma tissues was lower than that in grades Ⅲ and Ⅳ glioma tissues (P < 0.001). The positive expression rates of VM in glioma tissues and the normal brain tissues were 70% (42/60) and 0% (0/10), respectively. The number of VM in grades Ⅰ and Ⅱ glioma tissues was smaller than that in grades Ⅲ and Ⅳ glioma tissues (P = 0.003, P < 0.001). The expressions of Mig-7 and VM were associated with the pathologic grade of glioma (P < 0.001, P = 0.011). The median survival time of patients with low, moderate and high expression levels of Mig-7 were 85.00, 36.00 and 10.00 months, respectively (P < 0.05).Conclusion: The expression of Mig-7 can be observed in glioma tissues and is related to the pathologic grade of glioma. Mig-7 may promote the formation of VM and influnce the prognosis. DOI:10.3781/j.issn.1000-7431.2015.33.873