Emerging Resistance to Commonly Used Carbapenem (Imipenem and Meropenem) among the Gram Negative Bacteria in A Tertiary Care Centre of Central India

Carbapenems are well known for their broadest spectrum of clinical activity and utmost potency among the different β-lactam antibiotics. Unfortunately, the recent emergence of multidrug-resistant pathogens seriously threatens this class of lifesaving drugs. To evaluate the pattern and extent of resistance to carbapenem among gram negative bacteria isolated from blood culture at tertiary care centre. Method and material: A cross sectional observational study was conducted in a tertiary care centre. Data regarding culture and sensitivity was obtained from Microbiology department. Resistance to carbapenem was observed to be in 78.35% of gram negative isolates. Imipenem was found to be resistant in around 76.97% while meropenem was resistant in 79.74% of isolates. Terrific high level of resistance to the carbapenem is found among GNB, this is indeed is hazardous not only to patient but also to community.