Pharmacological Profile, Pharmacokinetics and Biotransformation of the 5-Lipoxygenase Inhibitor FLM 5011

The implication of lipoxygenase-mediated pathways of polyenoic fatty acid metabolism in inflammation, bronchial asthma and other diseases is today generally accepted. Nevertheless the precise role of lipoxygenase metabolites, in particular their interaction with other groups of inflammatory mediators, is yet far from clear. Specific inhibitors of lipoxygenases are valuable tools to gain deeper insight into the biological role of lipoxygenases and their reaction products.