418. AAV-Mediated sFLT-1 Gene Therapy for Ocular Neovascularization: Longevity, Toxicity and Efficacy Results from Mice and Monkeys

Purpose: To investigate the efficacy, longevity and toxicity of adeno-associated virus (AAV)-mediated expression of sFlt-1 in the mouse model of retinal neovascularization (trVEGF029) and in the laser induced monkey model of choroidal neovascularization (CNV).