Structural, Spectroscopic, Antiferromagnetic and in vitro antiproliferative studies of copper (II) pyrophosphate complex against Human breast cancer cell lines

Abstract In purpose to search for compounds of biological interest, we have succeeded in synthesizing a copper complex with polypyridine ligands. The architecture of the compound consists of O, N-donor entities, the pyrophosphate anion HP2O73− and the two heterocyclic molecules, 1,10-phenanthroline and 2,2′-bipyridine. X-ray diffraction study proves that our compound crystallizes in a monoclinic cell of space group P21/n. The atomic arrangement can be described by the aggregation of [(C10H8N2)(C12H10N2)Cu2(H2O)2(HP2O7)]+ cation, which contributes to the macrocyclic compound-complex. The second sphere of the cationic complex is localized the anion ClO4− to complete the neutrality. Magnetic studies show an antiferromagnetic coupling exchange between metal copper ions which mediated throw neighboring oxygen atom belonging from the pyrophosphate anion. The biological antiproliferative activity of the sample shows a relatively high cytotoxicity IC50 respectively toward MCF-7 breast cancer cell lines.