Nucleation of Multiple Buckled Structures in Intertwined DNA Double Helices
2017
We study the statistical-mechanical properties of intertwined double-helical DNAs (DNA braids).
In magnetic tweezers experiments we find that torsionally-stressed stretched braids supercoil via
an abrupt buckling transition, which is associated with nucleation of a braid end loop, and that
the buckled braid is characterized by proliferation of multiple domains. Differences between the
mechanics of DNA braids and supercoiled single DNAs can be understood as an effect of increased
bulkiness in the structure of the former. The experimental results are in accord with the predictions
of a previously-described statistical-mechanical model.
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