Chemically Modified Enzyme and Biomimetic Catalysts Electrodes

The chemically modified enzyme electrodes (CMEEs) and biomimetic catalysts (BC) based electrodes (BCEs) exhibit numerous remarkable properties, such as high sensitivity, specificity and stability. In this chapter mathematical models of several types of these biosensors are considered at stationary and transient conditions. Firstly, the action of CMEEs produced by modifying carbon electrodes with redox active component (mediator) and an enzyme is considered at stationary conditions. Then, the two compartment modeling is applied to the biosensor utilizing an ordered ping-pong scheme of the enzyme catalysed substrate conversion in the presence of the mediator. After that, an approach where two diffusion layers are modeled by one layer by introducing an effective diffusion coefficient is discussed and applied to a model comprising three layers. The final study is dedicated to analysis of biosensors based on biomimetic catalysts utilizing a combination of two kinds of redox interaction—a simple chemical second-order reaction and Michaelis-type redox reaction scheme. By applying these two types of reactions the influence of the physical and the kinetic parameters on the biosensor response is investigated.