Intermediate useful for preparation of nitrogen-containing polycyclic compound
1991
PURPOSE: To provide an intermediate useful for the production of a nitrogen- containing polycyclic compound used for treating bacterial infections. CONSTITUTION: (A) 3-Pyrrolidinemethanamines of formula I [R 3 is 1-4C alkyl, 3-6C cycloalkyl; R 4 is H, 1-4C alkyl, 2-4C hydroxyalkyl or R 7 CO-C (R 7 is 1-4C alkyl or 1-4C alkoxy]. (B) 2,7-Diazaspiro[4,4]nonane of formula II. (C) Ethyl[(3- pyrolidinyl)methyl] carbamate. (D) A compound of formula III (R 1 is H, 1-6C alkyl or cation; R 2 is 1-4C alkyl, vinyl, 2-4C haloalkyl or 2-4C hydroxyalkyl; X is CH, CCl, CF, C-OH, CO-1-3C alkyl, CNH-1-3C alkyl-N; and Y is H, F, Cl or Br) or IV (R 8 and R 9 are H or 1-3C alkyl). COPYRIGHT: (C)1992,JPO
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