Effects of atorvastatin and artichoke leaf tincture on oxidative stress in hypercholesterolemic rats.
2016
Backgroung/Aim. Since combining conventional drugs with herbal medicinal
products is in current research focus and possible of great interest as
therapy improvement way, the aim of this study was to determine the effects
of wellestablished antiatherosclerotic drug atorvastatin (CAS number
134523-00-5) and commercially available artichoke leaf tincture (ALTINC),
used as combined therapy, as well as to compare effects of these two
treatments separately. Methods. Experimental animals were divided into five
groups: the group I (the control group of rats fed with standard diet during
11 weeks), and the remaining 4 groups of rats (II, III, IV and V) fed with
standard diet during the first week and then with hypercholesterolemic diet
during the next 10 weeks. The group II of rats were left without treatment,
while in the groups III, IV and V were rats treated per os with atorvastatin
(1.15 mg/kg body wright − b.w.), ALTINC (0.1 mL/kg b.w.) and their
combination in same doses, respectively, for the last six weeks. Results. The
cholesterol rich diet led to pronounced hyperlipidemia which could not be
overcame with the therapy. However, the therapy showed positive effects on
abdominal aorta wall thickness and parameters of oxidative stress
(malondialdehyde − MDA, proxidative-antioxidative balance − PAB) and
antioxidative protection (reduced glutathione − GSH, paraoxanase 1 − PON1,
superoxide dismutase − SODA SH groups), especially ALTINC was successful in
oxidative status improvement. Conclusion. Separate treatments comparison
showed that artichoke leaf tincture is very potent antioxidant with
beneficial effects in early stages of atherosclerosis. Since atorvastatin and
constituents of ALTINC probably have different mechanisms of action,
simultaneous use of both therapies could be beneficial but should be further
investigated since our results showed that ALTINC is less effective when used
in combination with atorvastatin. [Projekat Ministarstva nauke Republike
Srbije, br. OI 175035 i br. 172041]
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
33
References
4
Citations
NaN
KQI