Design and fabrication of amoeba faced photonic crystal fiber for biosensing application

Abstract A newly designed Amoeba faced photonic crystal fiber (A-PCF) is introduced for the first time in the fields of fiber for biosensing and particularly to detect cancerous cells for instances- blood cancer (Jurkat), cervical cancer HeLa), adrenal glands cancer (PC12), breast cancer (MDA-MB-231, MCF-7) and skin cancer (Basal), etc. In fact, proposed PCF is fabricated after the simulation studies and the application for sensing is numerically investigated by the discrete finite element method (D-FEM) by the simulation of about 22,105 mesh elements. Moreover, the numerical analysis is justified by full vector simulation software COMSOL V-5.1 and considering the refractive indices from it. Also, different sections are considered for the analyte cavity to analyze the performance variations. Nonetheless, Few parameters like birefringence, coupling length, power fraction, transmittance, wavelength sensitivity, and transmittance sensitivity are evaluated through the refractive indices of the cancerous cell compared to its normal cell and the most optimum profile are respectively to 3.5 × 10−3, 900 µm, 0.891, -178 dB, 18115.94 nm/RIU and 6071.42 dB/RIU. Nonetheless, the fabrication of the PCF can be achieved by using current fabrication technology such as stack-and-draw, sol-gel or the extrusion and drilling techniques that help to overcome all the primary difficulties of the proposed PCF.