[The role of the sympathetic cholinergic pathway in the neurogenic control of the release of tissue-type plasminogen activator into the blood].

: In anesthetized cats, electric stimulation of the sympathetic chain induced vasoconstriction and release of t-PA from the vascular wall into the blood. Efferent stimulation of the sympathetic chain against the background of alpha-adrenoceptor blockade increased the blood flow and the t-PA activity. Atropin suppressed both the vascular relaxation and the t-PA release into the blood. A neurogenous mechanism controlling t-PA release from the vascular wall caused by activation of sympathetic cholinergic pathway and associated with excitation of vascular M-cholinoreceptors by acetylcholine, has been suggested.