Effect observation of titanium silicate for elderly patients with advanced and recurrent gastric cancer
2013
Objective To observe the short-term efficacy and toxicity of titanium silicate(S-1) in the treatment of elderly patients with advanced and recurrent gastric cancer.Methods Fifty-six elderly patients with advanced and recurrent gastric cancer were given S-1 80 mg/(m2 · d)orally,2 times/d for 14 days,then drug with drawal for 7 days,3 weeks for a cycle.Then the efficacy and toxicity after 2 cycles of treatment was evaluated.Results Fifty-six patients can be evaluated the efficacy.CR in 2 cases and PR in 19 cases,the overall response rate was 37.5% ; SD in 19 cases and PD in 16 cases,the disease control rate was 60.6%.The quality of life improved in 23 patients(41.1%),stabled in 27 patients(48.2%).The main adverse reactions were leukopenia,aglobulism,nausea and vomiting,diarrhea,skin pigmentation and rash.Conclusions S-1 in the treatment of elderly patients with advanced and recurrent gastric cancer has good effect,and the adverse reactions can be tolerated,so is worthy of promotion.
Key words:
Gastric cancer; S-1
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