A systematic review on correlation between biochemical and mechanical processes of lubricant film formation in joint replacement of the last 10 years

This study provides a systematic review of the synovial and simulated body fluid research for the last 10years (2006 to 2016). In particular, biochemical and mechanical properties of synovial fluid after joint replacement are focused, namely, the chemical composition of the formed lubricating film and structural changes of the associated proteins under mechanical loading. In summary, the formation of the film depends on pH, viscosity, and concentration of the solution, static, sliding, and rolling conditions and other factors related to the joint replacement. However, chemical changes of the synovial fluid proteins after the joint replacement are rarely addressed and require further attention. To this end, we provide a preliminary study of selected proteins within the synovial fluid using Raman spectroscopy. We conclude that chemical analysis together with the analysis of mechanical and biological properties of the synovial fluid after total joint replacement will help in comprehension of the process.