Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride

Vladimir Genukh Beylin,Norman L. Colbry,Om Prakash Goel,Jerome E. Haky,Donald R. Johnson,Judith L. Johnson,Gerald Kanter,Robert L. Leeds,Boguslawa Leja,Edward P. Lewis,Christopher D. Rithner,H. D. Hollis Showalter,Anthony D. Sercel,William R. Turner and,Susan E. Uhlendorf

Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride

1989

Vladimir Genukh Beylin
Norman L. Colbry
Om Prakash Goel
Jerome E. Haky
Donald R. Johnson
Judith L. Johnson
Gerald Kanter
Robert L. Leeds
Boguslawa Leja
Edward P. Lewis
Christopher D. Rithner
H. D. Hollis Showalter
Anthony D. Sercel
William R. Turner and
Susan E. Uhlendorf

Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of the synthetic sequences.

Keywords:

Organic chemistry
Anthrapyrazole
Chemistry
Anthrapyrazoles
PIROXANTRONE HYDROCHLORIDE

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