Wharton’s Jelly Mesenchymal Stem Cell-derived (WJ-MSC) exosomes for Severe Bronchopulmonary Dysplasia: A Dose-Finding Study

Background: Previously, we demonstrated that early administration of Wharton’s Jelly Mesenchymal Stem Cell-derived (WJ-MSC) exosomes attenuates pulmonary hypertension (PH) and improves lung structure in experimental bronchopulmonary dysplasia (BPD). The optimal dose is however not known. The purpose of this study was to determine the optimal WJ-MSC exosome dose for lung regeneration in severe BPD complicated by PH. Objective: To elucidate the most effective and safe MSC exosome dose to prevent neonatal hyperoxia-induced lung injury and PH. Design/Methods: …