Upper Urinary Tract Infections Are Associated with RANTES Promoter Polymorphism

We evaluated the association between MCP-1, CCR2, RANTES, and CCR5 gene polymorphisms and upper urinary tract infection in 273 children recruited in Northeast Italy. Statistical analysis of RANTES -403 G>A genotype frequencies showed that children carrying the RANTES -403 G allele are at higher risk for urinary tract infection, irrespective of vesicoureteral reflux.