Analytical Validation of an HCV Replicon-based Phenotypic Assay for Evaluating Replication Capacity and Susceptibility of Genotype 1a/1b Patient viruses to Polymerase Inhibitors

Con1 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Con1 S282T 13.48 0.41 0.77 0.40 0.64 0.68 0.33 Con1 C316Y 0.52 0.39 1.75 6.33 109.66 0.36 0.81 Con1 L392I 0.66 7.34 1.35 1.30 0.51 0.88 0.87 Con1 M423T ND ND >410 ND ND 1.16 ND Con1 Y448H 0.59 0.94 0.46 9.77 1.02 0.87 0.81 Con1 P495A 0.97 25.12 0.45 0.30 0.35 0.75 0.90 H77 0.72 0.48 1.38 4.69 0.99 0.92 0.82 H77 S282T 17.68 0.39 0.86 2.57 0.50 1.07 0.35 H77 P495L 0.71 >130.00 2.25 3.63 0.36 0.83 0.80