Analysis of the α-synuclein gene dosage variation associated with autosomal dominant form of Parkinson’s disease

Fifty-two patients that had Parkinson’s disease with autosomal dominant type of inheritance were analyzed for the presence of duplications and triplications in exons 4–6 of α-synuclein gene using real-time PCR with TaqMan probes. No mutations involving the examined exons dosage were revealed in α-synuclein gene. Thus, mutations modifying copy number of α-synuclein gene do not significantly affect the pathogenesis of the autosomal dominant form of Parkinson’s disease in patients from Russia.