Effect of pyridoxine on sodium glycolate-induced hyperoxaluria in rats.

Large doses of pyridoxine administration (10 mg pyridoxine-HCl100 g BW/day) failed to lower the hyperoxaluria in rats induced by sodium glycolate feeding (100 mg100 g BW/day). Urinary excretion of calcium was significantly decreased (P < 0.01) after the first week of glycolate treatment in both pyridoxine supplemented and non-supplemented groups, whereas citrate excretion was significantly increased (P < 0.05) after the first week only in glycolate and pyridoxine fed rats, when compared to their basal levels. Transaminase activities (GOT and GPT) of liver, kidney and RBC decreased significantly with sodium glycolate treatment, but the protective effect by pyridoxine supplementation was seen only in kidney GOT and GPT levels. While administration of such large amounts of pyridoxine alone, decreased liver and kidney transaminase activities, the erythrocyte GOT was significantly increased. It can be concluded that large amounts of pyridoxine fail to lower the hyperoxaluria induced by glycolate feeding in rats but on the other hand, this produces changes similar to those observed in pyridoxine deficiency.