Correlación de polimorfismos del gen COL1A2 con fluorosis dental en niños mexicanos

espanolLa fluorosis dental (FD) es la hipomineralizacion del esmalte dental causada por el aumento de la porosidad, cuya severidad se debe a una ingesta excesiva de fluor (F) con relacion dosis-respuesta durante el desarrollo del esmalte. El objetivo del trabajo fue determinar la correlacion de los polimorfismos rs810687 y rs411717 del gen colageno tipo 1 alfa 2 (COL1A2 ) con FD en ninos mexicanos de 10 a 12 anos, utilizando el Indice de Dean para establecer el grado de FD y PCR-HRM para la genotipificacion de los polimorfismos. Se incluyeron 100 ninos de 10.9 ± 0.78 anos; las frecuencias alelicas y genotipicas encontradas fueron: G = 52.5%, A = 47.5%, G/G = 27.5%, G/A = 49.8%, A/A = 22.5%, C = 63.3%, T = 36.5%, C/C = 40.3%, C/T = 46.3%, T/T = 13.3% de los polimorfismos rs810687 y rs411717, respectivamente, con un coeficiente de correlacion de Pearson r = – 0.017 (p > 0.05) con FD. Los resultados mostraron que no existia correlacion entre la FD y la presencia de los polimorfismos rs810687 y rs411717 del gen COL1A2. EnglishDental fluorosis (FD, for its achronym in spanish) is the hypomineralization of dental enamel caused by increased porosity, severity is due to an excessive intake of fluoride with a dose-response relationship during enamel development. The objective of this study was to determine correlation of rs810687 and rs411717 polymorphisms of (colageno tipo 1 alfa 2) COL1A2 gene with FD in Mexican children aged 10 to 12 years, using Dean Index to establish degree of FD and PCR-HRM for polymorphisms genotyping. We included 100 children of 10.9 ± 0.78 years; Allele and genotype frequencies found were: G = 52.5%, A = 47.5%, G/G = 27.5%, G/A = 49.8%, A/A = 22.5%, C = 63.3%, T = 36.5%, C/C = 40.3%, C/T = 46.3%, T/T = 13.3% of rs810687 and rs411717 polymorphisms respectively; with a Pearson correlation coefficient r = – 0.017 (p > 0.05) with FD. Results showed that there was no correlation between FD and presence of rs810687 and rs411717 polymorphisms of the COL1A2 gene.