Association of T-786C polymorphism of endothelial oxide synthase gene with rheumatoid arthritis

The aim of the study was to analyze the frequency of alleles/genotypes of eNOS gene T-786C polymorphism in patients with rheumatoid arthritis (RA), Arterial Hypertension (AH), Obesity (AO), type 2 Diabetes Mellitus (DM2), and their association with severity and RA clinical manifestation. The eNOS T-786C gene polymorphism was analyzed by polymerase chain reaction in 60 patients with RA and 20 healthy individuals. Wild T-allele dominates over mutant C-allele in the population by 30% (р10 by 37.94% (р=0.004) and 73.92% (р10 by 47.82% (р=0.001); all CC-genotype patients complained of heart pain; morning stiffness with duration of ≥6 hours didn't depend on analyzed gene polymorphism.