Application effect of sevoflurane in the cesarean section of pregnant women with pernicious placenta previa and its influence on maternal hemodynamics.

OBJECTIVE To evaluate the application effect of sevoflurane in pregnant women with pernicious placenta previa who conduct the cesarean section and its influence on maternal hemodynamics. METHODS A total of 94 women with pernicious placenta previa (PPP) admitted to our hospital were recruited in this study. They were randomly divided into two groups, with 47 each group. The control group was given ketamine, propofol and rocuronium while the observation group was given sevoflurane base on conventional general anesthesia. The available data, intraoperative indexes, coagulation function before and after operation, hemodynamics, umbilical arterial partial pressure of oxygen and carbon dioxide before the procedure (T0), 5 min after anesthesia (T1), 15 min after anesthesia (T2) and during fetal delivery (T4) were observed. The Apgar scores of 1 min, 5 min and 10 min after birth were recorded. RESULTS No significant difference was seen in related indicators during operation and blood coagulation function before and after the operation between the two groups (P>0.05). The diastolic blood pressure and systolic blood pressure decreased at T1, T2 and T3 compared with T0 time (P<0.05). The decrease was more evident in the control group than in the observation group (P<0.001). The mean arterial pressure in the two groups at T1, T2 and T3 was higher than that at T0 (P<0.05). At T2, the increase in the control group was more obvious than that in the observation group (P<0.001). The heart rate at T1 and T2 was higher than that at T0 (P<0.05). Compared with the control group, the oxygen pressure increased and the carbon dioxide pressure decreased in the observation group (P<0.001). The Apgar score of the observation group was higher than that of the control group at 1 min and 5 min (P<0.001). CONCLUSION Sevoflurane can stabilize hemodynamics, improve neonatal oxygen uptake rate and increase the safety of operation without affecting coagulation function, which is worthy of clinical application.