Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells

Brock A. Peters,Bahram Ghaffarzadeh Kermani,Andrew Sparks,Oleg Alferov,Peter Hong,Andrei Alexeev,Yuan Jiang,Fredrik Dahl,Y. Tom Tang,Juergen Haas,Kimberly Robasky,Alexander Wait Zaranek,Je-Hyuk Lee,Madeleine P. Ball,Joseph E. Peterson,Helena Perazich,George Yeung,Jia Liu,Linsu Chen,Michael I. Kennemer,Kaliprasad Pothuraju,Karel Konvicka,Mike Tsoupko-Sitnikov,Krishna Pant,Jessica Ebert,Geoffrey B. Nilsen,Jonathan Baccash,Aaron L. Halpern,George M. Church,Radoje Drmanac

Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells

2012

A new DNA analysis method termed long fragment read technology is described, and the approach is used to determine parental haplotypes and to sequence human genomes cost-effectively and accurately from only 10 to 20 cells.

Keywords:

Genomics
Human genome
Exome sequencing
DNA
Haplotype
Mutation
Hybrid genome assembly
Whole genome sequencing
Biology
Genetics
Personal genomics
Genome
DNA sequencing

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