The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Geeta Sapra,Yow Keat Tham,Nelly Cemerlang,Aya Matsumoto,Helen Kiriazis,Bianca C. Bernardo,Darren C. Henstridge,Jenny Y. Y. Ooi,Lynette Pretorius,Esther J.H. Boey,Lim L,Junichi Sadoshima,Peter J. Meikle,Natalie A. Mellet,Elizabeth A. Woodcock,Silvana Marasco,Tomomi Ueyama,Xiao-Jun Du,Mark A. Febbraio,McMullen

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

2014

Atrial fibrillation and heart failure often coexist but are difficult to treat. Here the authors report a therapeutic strategy for atrial fibrillation and heart failure in mice, based on the activating effect of a small molecule, BGP-15, on IGF1 receptor signalling.

Keywords:

Small molecule
Atrial fibrillation
Heart failure
Molecular biology
Receptor
Internal medicine
Biology
Cardiology
Growth factor
Insulin-like growth factor 1 receptor
Cardiac function curve
Caveolin 3
Caveolin 1

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